The lab’s current research is focused on how neonatal intraventricular hemorrhage (bleeding into the brain of premature infants) causes inflammation and impedes normal brain development. The lab studies how surgical and new medical interventions can protect the brain from injury.

The Miller lab has made significant advances in pediatric brain injury research as evidenced by numerous publications and multi-million dollar grants from the NIH.

John Bufalino 3/6/26 John Bufalino 3/6/26

Acute brain inflammation, white matter oxidativestress, and myelin deficiency in a model of neonatalintraventricular hemorrhage

John Bufalino 3/6/26 John Bufalino 3/6/26

Safety of Indocyanine Green Microdosing for ClinicalImaging of CSF Ventricular Dynamics and Extracranial Outflow

John Bufalino 3/6/26 John Bufalino 3/6/26

A Sublethal Dose of TNF Alpha Potentiates Kainate-Induced Excitotoxicity in Optic Nerve Oligodendrocytes

John Bufalino 3/6/26 John Bufalino 3/6/26

Neonatal hydrocephalus leads to white matter neuroinflammation and injury in the corpus callosum of Ccdc39 hydrocephalic mice

John Bufalino 3/6/26 John Bufalino 3/6/26

A lumbar arteriovenous fistula presenting with intraventricular hemorrhage and hydrocephalus

John Bufalino 3/6/26 John Bufalino 3/6/26

Modeling brain injury: Neonatalintraventricular hemorrhage

John Bufalino 3/6/26 John Bufalino 3/6/26

Cerebral protection by hypoxicpreconditioning in a murine model of focalischemia-reperfusion

John Bufalino 3/6/26 John Bufalino 3/6/26

Applications of a robotic stereotactic arm for pediatricepilepsy and neurooncology surgery

John Bufalino 2/20/26 John Bufalino 2/20/26

Azithromycin reduces hemoglobin-induced innate neuroimmune activation

John Bufalino 2/20/26 John Bufalino 2/20/26

Innate immune activation and white matter injury in a rat model neonatal intraventricular hemorrhage are dependent ondevelopmental stage

John Bufalino 2/20/26 John Bufalino 2/20/26

Developmental stage of oligodendrocytes determines their response to activated microglia in vitro

John Bufalino 10/4/22 John Bufalino 10/4/22

Modeling Neonatal Intraventricular Hemorrhage through Intraventricular Injection of Hemoglobin

John Bufalino 9/29/22 John Bufalino 9/29/22

Developmental stage-dependent transcriptomic responses to neonatal intraventricular hemorrhage

GRANT FUNDING

Thank you to our past and present supporters who have propelled our research forward

Awards

NIH, NINDS- R01

NIH, NINDS- K08

Hydrocephalus Association- Innovator Award

ACADEMIC RIGOR

Dr. Miller is a leading voice in pediatric brain injury research. He serves as a scientific reviewer on multiple review committees including for the DOD and NIH.

Dr. Miller brings a unique expertise combining his neurosurgical experiences with his neuroscience background. He has been an invited speaker to many professional society conferences as well as a valued peer reviewer for clinical and scientific journals.